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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause a rise in methadone plasma concentrations, which could induce possibly fatal respiratory depression. Also, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may end in an increase in methadone plasma focus.